Reader Kin is abnormal in leaf acid grafting gene on 2020-6-5, is it true? Response:
Hello, my wife was detected as ac in a1298c in mthfr gene detection, so the doctor opened a low dose of aspirin, vitamin B and high dose of leaf acid (4000 mg per day). I would like to ask if such a high dose of active leaf acid will have adverse effects on the wife or the fetus? Can excessive amounts of leaf acid be discharged by itself?
The "Mthfr Gene Testing" as determined as ac anomaly in a1298c" by this reader occurred at the 1298th position of the mthfr gene, and I am abnormal in the leaf acid gene, is it true? The so-called "Leaf Acid Gene Anomaly" occurred in position 677. The change that occurs at the 677th position will affect about 10% of the function of mthfr, but the change that occurs at the 1298th position will not affect the function of mthfr. Whether it happens at position 677 or at position 1298, I have abnormal leaves in the leaf acid gene, is it true? It has been said that the so-called "Anomaly" is actually just "The Change", while the so-called "Yellow Acid Gene Anomaly" is just an advertising gimmick compiled by a gene testing company to make money.
The reader said that the doctor asked his wife to take 4,000 mg of leaf acid (synthetic vitamin B9) a day, but he should have misrepresented "Microgram" as "Microgram" (note: 1 mg = 1,000 microgram). According to the CDC in the United States, the recommended daily dose of adults is 400 micrograms, and only one person needs to take a dose of 4000 micrograms. That is, a woman who has had a fetus in "Neurotuberculosis Incompleteness", and she plans to get pregnant again within one month (Note: For "Neurotuberculosis Incompleteness", please see if pregnant women need to replenish leaves).
The reader asked whether the excessive amount of leaf acid can be excreted by itself is a common misconception that no matter how much water-soluble vitamins are taken, it doesn't matter because they will be excreted from the body through urine. For example, a professor of professions at the Chinese University of Hong Kong said this when he was interviewed by a briefing (please see the part under the two emoticon images in the sticker). But in fact, according to a 2014 paper Folic Acid Handling by the Human Gut: Implications for Food Fortification and Supplementation, our brains will almost completely decompose and transform the leaf acid from food into active leaf acid, which is almost completely unable to decompose leaf acid from supplements, resulting in the accumulation of unreliable leaf acid in the blood. Many studies have shown that the blood containing too much unreliminated leaf acid is related to many diseases. For example, it can be seen from the title of a 2017 outline that it is absolutely essential to take up a large amount of leaf acid. Please see The adverse effects of an excessive felic acid intake.
As for the question of "Whether such a high dose of active leaf acid has adverse effects on the wife or the fetus", this is indeed a question that needs attention. A study published in 2015 found that the leaves and unrepresented leaves in Canadian pregnant women themselves and in their blood were highly concentrated. The paper also states in the discussion: "The functional consequences of high concentrations of leaf acid and unprotected leaf acid in pregnant women and fetal blood deserve further study because excessive leaf acid status may affect long-term health results for offspring." See High Concentrations of Folate and Unmetabolized Folic Acid in a Cohort of Pregnant Canadian Women and Umbilical Cord Blood.
A study published in 2017 also found that taking high doses of leaf acid (1,000 micrograms per day or more) before and after pregnancy is related to the low weight of the child at birth. See High doses of felic acid in the periconceptional period and risk of low weight for gestational age at birth in a population based cohort study.
Similarly, a study published in 2017 also found that children born to pregnant women who took too much leaf acid will have a more severe brain development.. See Effect of Maternal High Dosages of Folic Acid Supplements on Neurocognitive Development in Children at 4-5 Y of Age: The Prospective Birth Cohort Infancia Y Medio Ambiente (INMA) Study.
The National Institute of Health in the United States has an Office of Dietary Supplements that provides information on dietary supplements, and the webpage about leaf acid is: https://ods.od.nih.gov/factsheets/Folate-HealthProfessional/. There is a section on this page that discusses "Overdose of Leaf Acid Intake and Health Risks". I translate its focus as follows:
A large amount of leaf acid can correct the sexual blood of giant teenage cells, but cannot correct the neural damage caused by the lack of vitamin B12. Therefore, some experts have been worried that the infusion of high leaf acid supplements may cause “ Vitamine B12 deficiency, which leads to neurologic damage to an irreversible state. Questions about this possibility remain, but the focus of people's attention has shifted to a large amount of leaf acid that may increase the possibility of vitamin B12 lacking blood and cognitive symptoms.People are also worried that the infusion of hyperleaf acid may accelerate the development of pre-tumor diseases, especially in the development of kidney cancer. In addition, studies have shown that adding 1,000 micrograms or more of leaf acid from the supplement every day before and after pregnancy will cause her child to develop well. If the infiltration of
leaves exceeds the human body's ability to restore it, it will lead to too much unreliable leaves in the body, thereby reducing the amount and activity of natural killer cells. That is, too much leaf acid may reduce immunity. In addition, studies have found that unrecognized leaf acid may be related to cognitive impairment in the elderly. These potential negative health consequences have not been well understood and require further research.
Original text: The adverse effects of excessive leaf acid